Summary of a Meeting on the Origin of Pandemic Influenza Viruses
Identifieur interne : 002496 ( Main/Exploration ); précédent : 002495; suivant : 002497Summary of a Meeting on the Origin of Pandemic Influenza Viruses
Auteurs : W. Graeme Laver [République populaire de Chine] ; Robert G. Webster [République populaire de Chine] ; C. M. Chu [République populaire de Chine]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1984.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (immunologie), Chine, Grippe humaine (), Grippe humaine (microbiologie), Gènes viraux, Humains, Hémagglutinines virales (immunologie), Lymphocytes T cytotoxiques (immunologie), Orthomyxoviridae (génétique), Orthomyxoviridae (immunologie), Orthomyxoviridae (physiologie), Recombinaison génétique, Réplication virale, Réservoirs d'agents pathogènes, Sialidase (génétique), Sialidase (immunologie), Structures macromoléculaires, Vaccins antigrippaux (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (physiologie), Écologie, Épitopes (immunologie).
- MESH :
- génétique : Orthomyxoviridae, Sialidase, Virus de la grippe A.
- immunologie : Antigènes viraux, Hémagglutinines virales, Lymphocytes T cytotoxiques, Orthomyxoviridae, Sialidase, Vaccins antigrippaux, Épitopes.
- microbiologie : Grippe humaine.
- physiologie : Orthomyxoviridae, Virus de la grippe A.
- Animaux, Chine, Grippe humaine, Gènes viraux, Humains, Recombinaison génétique, Réplication virale, Réservoirs d'agents pathogènes, Structures macromoléculaires, Écologie.
- Pascal (Inist)
- Wicri :
- geographic : République populaire de Chine.
- topic : Chimie, Homme, Vaccination.
English descriptors
- KwdEn :
- Animals, Antigenicity, Antigens, Viral (immunology), Asia, Chemistry, China, Disease Reservoirs, Ecology, Epidemic, Epidemiology, Epitopes (immunology), Gene expression, Genes, Viral, Genome, Hemagglutinins, Viral (immunology), Human, Humans, Infection, Influenza, Influenza A virus (genetics), Influenza A virus (physiology), Influenza Vaccines (immunology), Influenza, Human (microbiology), Influenza, Human (therapy), Influenzavirus A, Macromolecular Substances, Molecular structure, Neuraminidase (genetics), Neuraminidase (immunology), Orthomyxoviridae (genetics), Orthomyxoviridae (immunology), Orthomyxoviridae (physiology), Prevention, Recombination, Genetic, Replication, Reservoir, Sanitary surveillance, T-Lymphocytes, Cytotoxic (immunology), Vaccination, Viral disease, Virus, Virus Replication.
- MESH :
- chemical , genetics : Neuraminidase.
- chemical , immunology : Antigens, Viral, Epitopes, Hemagglutinins, Viral, Influenza Vaccines, Neuraminidase.
- geographic : China, Macromolecular Substances.
- genetics : Influenza A virus, Orthomyxoviridae.
- immunology : Orthomyxoviridae, T-Lymphocytes, Cytotoxic.
- microbiology : Influenza, Human.
- physiology : Influenza A virus, Orthomyxoviridae.
- therapy : Influenza, Human.
- Animals, Disease Reservoirs, Ecology, Genes, Viral, Humans, Recombination, Genetic, Virus Replication.
Abstract
Influenza type A virus periodically undergoes major antigenic shifts in which the hemagglutinin (HAG) and sometimes the neuraminidase (NA) antigens are replaced by HAG and NA antigens of another subtype. Three such shifts have taken place since the virus was first isolated, and all appear to have occurred in China. The way in which these “new” influenza type A viruses suddenly appear (or reappear) in the human population is not known. At a meeting held in Beijing, China, on November 10–12, 1982, participants discussed the latest findings on the molecular biology of influenza viruses and on aspects of their ecology that may offer insight into the factors responsible for the origin of pandemic influenza viruses. Information obtained in earlier studies has provided some clues about how the antigenic shifts may occur. For example, the H3N2 virus has been found to be a recombinant deriving seven of its eight genes from an H2N2 strain and gene 4 (which encodes for the HAG) from some other virus, possibly an avian influenza virus of the H3 subtype [1–3]. In addition, studies of the genome of the HINI virus that appeared in Anshan, China, in 1977 have shown that this virus almost certainly underwent no replication for 27 years. This finding suggests that the virus existed in an animal reservoir during this period [4, 5].
Url:
DOI: 10.1093/infdis/149.1.108
Affiliations:
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Chu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, Australia, Memphis, Tennessee, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1984-01">1984</date><biblScope unit="vol">149</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="108">108</biblScope><biblScope unit="page" to="115">115</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno 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(genetics)</term><term>Orthomyxoviridae (immunology)</term><term>Orthomyxoviridae (physiology)</term><term>Prevention</term><term>Recombination, Genetic</term><term>Replication</term><term>Reservoir</term><term>Sanitary surveillance</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Vaccination</term><term>Viral disease</term><term>Virus</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes viraux (immunologie)</term><term>Chine</term><term>Grippe humaine ()</term><term>Grippe humaine (microbiologie)</term><term>Gènes viraux</term><term>Humains</term><term>Hémagglutinines virales (immunologie)</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Orthomyxoviridae (génétique)</term><term>Orthomyxoviridae (immunologie)</term><term>Orthomyxoviridae (physiologie)</term><term>Recombinaison génétique</term><term>Réplication virale</term><term>Réservoirs d'agents pathogènes</term><term>Sialidase (génétique)</term><term>Sialidase (immunologie)</term><term>Structures macromoléculaires</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (physiologie)</term><term>Écologie</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes</term><term>Hemagglutinins, Viral</term><term>Influenza Vaccines</term><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term><term>Macromolecular Substances</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Orthomyxoviridae</term><term>Sialidase</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Hémagglutinines virales</term><term>Lymphocytes T cytotoxiques</term><term>Orthomyxoviridae</term><term>Sialidase</term><term>Vaccins antigrippaux</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Orthomyxoviridae</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A 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A</term><term>Prévention</term><term>Réplication</term><term>Réservoir</term><term>Structure moléculaire</term><term>Surveillance sanitaire</term><term>Vaccination</term><term>Variant H1N1</term><term>Variant H2N2</term><term>Variant H3N2</term><term>Virose</term><term>Virus</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chimie</term><term>Homme</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Influenza type A virus periodically undergoes major antigenic shifts in which the hemagglutinin (HAG) and sometimes the neuraminidase (NA) antigens are replaced by HAG and NA antigens of another subtype. Three such shifts have taken place since the virus was first isolated, and all appear to have occurred in China. The way in which these “new” influenza type A viruses suddenly appear (or reappear) in the human population is not known. At a meeting held in Beijing, China, on November 10–12, 1982, participants discussed the latest findings on the molecular biology of influenza viruses and on aspects of their ecology that may offer insight into the factors responsible for the origin of pandemic influenza viruses. Information obtained in earlier studies has provided some clues about how the antigenic shifts may occur. For example, the H3N2 virus has been found to be a recombinant deriving seven of its eight genes from an H2N2 strain and gene 4 (which encodes for the HAG) from some other virus, possibly an avian influenza virus of the H3 subtype [1–3]. In addition, studies of the genome of the HINI virus that appeared in Anshan, China, in 1977 have shown that this virus almost certainly underwent no replication for 27 years. This finding suggests that the virus existed in an animal reservoir during this period [4, 5].</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Laver, W Graeme" sort="Laver, W Graeme" uniqKey="Laver W" first="W. Graeme" last="Laver">W. Graeme Laver</name></noRegion><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C. M." last="Chu">C. M. Chu</name><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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